Psychostimulant effect of levodopa: reversing sensitisation is possible.
Identifieur interne : 000C49 ( Main/Exploration ); précédent : 000C48; suivant : 000C50Psychostimulant effect of levodopa: reversing sensitisation is possible.
Auteurs : Anna Castrioto [France] ; Andrea Kistner ; Hélène Klinger ; Eugénie Lhommée ; Emmanuelle Schmitt ; Valérie Fraix ; Stephan Chabardès ; Patrick Mertens ; Jean-Louis Quesada ; Emmanuel Broussolle ; Pierre Pollak ; Stéphane C. Thobois ; Paul KrackSource :
- Journal of neurology, neurosurgery, and psychiatry [ 1468-330X ] ; 2013.
English descriptors
- KwdEn :
- Anxiety (chemically induced), Anxiety (complications), Basal Ganglia (drug effects), Deep Brain Stimulation (methods), Deep Brain Stimulation (psychology), Depression (chemically induced), Depression (complications), Dopamine Agonists (adverse effects), Dopamine Agonists (therapeutic use), Dyskinesia, Drug-Induced (complications), Dyskinesia, Drug-Induced (therapy), Euphoria (drug effects), Female, Humans, Levodopa (adverse effects), Levodopa (pharmacology), Male, Middle Aged, Motivation (drug effects), Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (therapy), Psychiatric Status Rating Scales (statistics & numerical data), Severity of Illness Index, Subthalamic Nucleus (physiology).
- MESH :
- chemical , adverse effects : Dopamine Agonists, Levodopa.
- chemically induced : Anxiety, Depression.
- complications : Anxiety, Depression, Dyskinesia, Drug-Induced, Parkinson Disease.
- drug effects : Basal Ganglia, Euphoria, Motivation.
- drug therapy : Parkinson Disease.
- methods : Deep Brain Stimulation.
- chemical , pharmacology : Levodopa.
- physiology : Subthalamic Nucleus.
- psychology : Deep Brain Stimulation.
- statistics & numerical data : Psychiatric Status Rating Scales.
- chemical , therapeutic use : Dopamine Agonists.
- therapy : Dyskinesia, Drug-Induced, Parkinson Disease.
- Female, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Levodopa therapy in Parkinson's disease (PD) is associated with non-motor complications resulting from sensitisation of the ventral striatum system. Recent studies showed an improvement in non-motor complications in PD patients with subthalamic stimulation. We hypothesised that ventral striatum desensitisation might contribute to this improvement.
DOI: 10.1136/jnnp-2012-302444
PubMed: 22991345
Affiliations:
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Le document en format XML
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Thobois</name></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name></author></analytic><series><title level="j">Journal of neurology, neurosurgery, and psychiatry</title><idno type="eISSN">1468-330X</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anxiety (chemically induced)</term><term>Anxiety (complications)</term><term>Basal Ganglia (drug effects)</term><term>Deep Brain Stimulation (methods)</term><term>Deep Brain Stimulation (psychology)</term><term>Depression (chemically induced)</term><term>Depression (complications)</term><term>Dopamine Agonists (adverse effects)</term><term>Dopamine Agonists (therapeutic use)</term><term>Dyskinesia, Drug-Induced (complications)</term><term>Dyskinesia, Drug-Induced (therapy)</term><term>Euphoria (drug effects)</term><term>Female</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>Levodopa (pharmacology)</term><term>Male</term><term>Middle Aged</term><term>Motivation (drug effects)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (therapy)</term><term>Psychiatric Status Rating Scales (statistics & numerical data)</term><term>Severity of Illness Index</term><term>Subthalamic Nucleus (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Dopamine Agonists</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Anxiety</term><term>Depression</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Anxiety</term><term>Depression</term><term>Dyskinesia, Drug-Induced</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Basal Ganglia</term><term>Euphoria</term><term>Motivation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Psychiatric Status Rating Scales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa therapy in Parkinson's disease (PD) is associated with non-motor complications resulting from sensitisation of the ventral striatum system. Recent studies showed an improvement in non-motor complications in PD patients with subthalamic stimulation. We hypothesised that ventral striatum desensitisation might contribute to this improvement.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region></list><tree><noCountry><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stephan" last="Chabardès">Stephan Chabardès</name><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><name sortKey="Kistner, Andrea" sort="Kistner, Andrea" uniqKey="Kistner A" first="Andrea" last="Kistner">Andrea Kistner</name><name sortKey="Klinger, Helene" sort="Klinger, Helene" uniqKey="Klinger H" first="Hélène" last="Klinger">Hélène Klinger</name><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><name sortKey="Lhommee, Eugenie" sort="Lhommee, Eugenie" uniqKey="Lhommee E" first="Eugénie" last="Lhommée">Eugénie Lhommée</name><name sortKey="Mertens, Patrick" sort="Mertens, Patrick" uniqKey="Mertens P" first="Patrick" last="Mertens">Patrick Mertens</name><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><name sortKey="Quesada, Jean Louis" sort="Quesada, Jean Louis" uniqKey="Quesada J" first="Jean-Louis" last="Quesada">Jean-Louis Quesada</name><name sortKey="Schmitt, Emmanuelle" sort="Schmitt, Emmanuelle" uniqKey="Schmitt E" first="Emmanuelle" last="Schmitt">Emmanuelle Schmitt</name><name sortKey="Thobois, Stephane C" sort="Thobois, Stephane C" uniqKey="Thobois S" first="Stéphane C" last="Thobois">Stéphane C. Thobois</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Castrioto, Anna" sort="Castrioto, Anna" uniqKey="Castrioto A" first="Anna" last="Castrioto">Anna Castrioto</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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